Research Progress of Polymer Displays and Energy Materials Laboratory in the Field of Multifunctional Advanced Materials
In recent years, SMSE’s Polymer Displays and Energy Materials Research Team has focused heavily on the field of new advanced materials and multi-functional common transmission systems. Through a series of recent research advancements, the design and preparation of a new multi-functional advanced material system, and important research progress in biomedical science, the research team has succeed in completing its work and publishing it in the distinguished academic journal "Advanced Materials." (“Advanced Materials” 2016, 28, 10195-10203). (Impact Factor 18.960).
In the biomedical system, the multifunctional drug delivery system with biocompatibility is the key to the treatment of cancer and the application of advanced biomedical medicine. The drug combination therapy system can effectively reduce drug resistance and dosage of drugs. Therefore, the preparation of biocompatible nano-functional materials and the construction of a multifunctional drug delivery and release system platform for biomedical applications has been a highly sought-after objective in the interdisciplinary field of life science and material science. At the same time, the research and development of anticancer drugs, antibodies, three-dimensional nano-deoxyribonucleic acid and multifunctional nanomaterials with photothermal effects all have important theoretical and practical applications.
Construction of a multi-porous nano-silicon ball with multiple drugs, three-dimensional deoxyribonucleic acid, antibodies, and gold nanorods, with a dual emulsion common-delivery system (Advanced Materials, 2016, 28 (46), 10195-10203)
To obtain the key features outlined above, the Polymer Displays and Energy Materials Research Team designed and produced porous nano-silicon spheres, gold nanorods and three micro-nano-DNA and biocompatible dual emulsion systems, which have a heat-transfer system and are used to load molecular targeting drugs, three-dimensional DNA and antibodies, allowing them to be successfully used in biomedical science applications of anticancer drug complex systems. At this point, several things occur: the new composite material can effectively load gold nanorods and porous nano-silicon spheres, with the nano-gold rods endowing the material with excellent photothermal effect and increasing the loading efficiency of water-soluble drugs and three-dimensional deoxyribonucleic acid; porous silicon spheres can increase the loading efficiency of hydrophobic drugs and the biocompatibility of the material; the double emulsion system can effectively prevent the cross contamination between the substances in each phase; and the multifunctional material double emulsion system can effectively load the antibody and protect the activity of the antibody. Finally, the multifunctional material platform system can simultaneously load anticancer drugs of different properties, and with good biocompatibility and light-heat effect, it can kill cancer cells more effectively through synergistic action and target action of various drugs. All this leads to synergistic action between drugs and DNA or antibodies, thus reducing drug resistance and side effects of drugs and hence making it an ideal drug loading and conveying material system.
At present, this work has been published in “Advanced Materials.” Due to the importance of this paper, the journal was selected as the first volume of the "Advanced Materials" and after publication, the research project’s findings received widespread praise both domestically and internationally.